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Microbial Pathogenesis

Basic insights regarding the mechanisms of the host-pathogen relationship are essential to improvements in infectious disease prevention, vaccine development, and antimicrobial drug design. MMG faculty members are investigating the molecular biology and host immune responses to a diverse group of human pathogens responsible for tuberculosis, AIDS, yellow fever, dengue fever, tularemia, and Clostridia-associated food poisoning.

Dr. Jim Bina
James E. Bina
Dr. Jennifer Bomberger
Jennifer Bomberger
Associate Professor
Dr. Vaughn Cooper
Vaughn S Cooper
Dr. JoAnne Flynn
JoAnne L. Flynn
Distinguished Professor
Dr. Seema Lakdawala
Seema S. Lakdawala
Associate Professor
Dr. Li
Jihong Li
Research Instructor
Dr. McClane
Bruce A. McClane
Anthony R. Richardson
Associate Professor
Dr. Scanga
Charles A. Scanga
Research Associate Professor
Gary Thomas

Associated Labs

Apetrei Lab 

My laboratory is interested in the study of the HIV/ SIV diversity and pathogenesis. The AIDS pandemic is produced by two different viruses, HIV-1 and HIV-2. These two viruses resulted from cross-species transmissions of SIVs, the viruses that naturally infect nonhuman primate species (NHPs) in Africa.  Learn more>

Bina Lab 

Our research is centered on defining the molecular mechanisms used by bacteria to resist antibiotics and cause disease in humans. Our work currently focuses on two important gram negative human pathogens: Vibrio cholerae and Francisella tularensisLearn more>

Bomberger Lab

My research program is focused on understanding host-pathogen interactions, and more specifically, how each influences the other during an infection.  Emerging evidence reveals that pathogens have the ability to modulate the host response to infection, while at the same time, respond to host defense by altering their virulence and antibiotic resistance. Learn more>

Cooper Lab

The primary goal of our laboratory is to understand how bacterial populations evolve and adapt to colonize hosts and cause disease. We are particularly focused on how bacterial populations form complex communities within biofilms and how cells perceive cues to attach or disperse. Learn more>

Flynn Lab

My primary interest is in the interaction of pathogens with the host, with special emphasis on the immune mechanisms that protect against or exacerbate disease. Our focus is on Mycobacterium tuberculosis, the organism responsible for tuberculosis, which causes 2 million deaths per year worldwide. Learn more>

Klimstra Lab 

The goal has been to define the host and viral factors that determine the success or failure of the innate immune response to infection with arthropod-borne viruses. Learn more>

Lakdawala Lab

Our lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses. Learn more>

McClane Lab

Our research is focused on understanding bacterial pathogenesis, which remains a major medical problem in both developing and developed countries. Learn more>

Richardson Lab

The Richardson Lab is primarily focused on the effects of immunometabolism on infectious disease outcomes. Specifically, we study immunometabolism in the context of infections caused by the Gram-positive pathogen Staphylococcus aureus. Learn more>

Thomas Lab

Our research program focuses on signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease. These studies were grounded by our identification of the proprotein convertase furin, which is the first member of a family of secretory pathway-localized endoproteases that catalyze the activation of bioactive proteins and peptide hormones. Learn more>

Associated Publications

Diedrich, C. R; and Flynn, J. L. (2011) HIV-1/mycobaterium tuberculosis co-infection immunology: How does HIV exacerbate TB? Infect Immun. 79: 1407-1417. | View Abstract
Ma, M; Vidal, J; Saputo, J; McClane, B. A; and Uzal, F. (2011) The VirS/VirR Two-Component System Regulates the Anaerobic Cytotoxicity, Intestinal Pathogenicity, and Enterotoxemic Lethality of Clostridium perfringens Type C Isolate CN3685. MBio. 2: e00338-10. | View Abstract
George, M. P; Brower, A; Kling, H; Shipley, T; Kristoff, J; Reinhart, T. A; Murphey-Corb, M; Gladwin, M. T; Champion, H. C; Morris, A; and Norris, K. A. (2011) Pulmonary Vascular Lesions Are Common in SIV- and SHIV-env-Infected Macaques. AIDS Res Hum Retroviruses. 27: 103-111. | View Abstract