Patrick S. Moore, MD, MPH

Distinguished Professor

Dr. Moore


Fax: 412-623-7715

1.8C Hillman Cancer Center

5117 Centre Avenue

Pittsburgh, PA 15213-1862


MD, University of Utah

MPH in Epidemiology, University of California, Berkeley

Research Summary

Our lab investigates viral causes of human malignancy and identifies new cancer-causing viruses using digital transcriptome subtraction. We currently focus on two agents we have discovered, KSHV (the viral cause of Kaposi’s sarcoma) and MCV (the viral cause for most Merkel cell carcinomas). We focus on the basic molecular virology of transformation as well as develop assays that have clinical value in detecting tumor virus infection. Most recently, we have characterized MCV mutations that truncate the MCV T antigen helicase to disable viral replication in tumors. We have also developed MCV T antigen monoclonal antibodies and virus-like particle serologic tests that allow us to screen patients and tissues for MCV infection. Additional research involves the search for potential KSHV vaccine candidates through analysis of latent KSHV protein immune processing.  

Research Lab Affiliation


Kwun, H.J; Chang, Y. and Moore, P.S. (2017) Protein-mediated viral latency is a novel mechanism for Merkel cell polyomavirus persistence. Proc Natl Acad Sci USA. 114: E4040-E4047. |  View Abstract

Velasquez C, Cheng E, Shuda M, Lee-Oesterreich PJ, Pogge von Strandmann L, Gritsenko MA, Jacobs JM, Moore PS and Chang Y. (2016) Mitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformation. Proc Natl Acad Sci USA. 113: 8466-8471. |  View Abstract

Toptan, T; Yousem, S.A; Ho, J; Matsushima, Y; Stabile, L.P; Fernandez-Figueras, M.T; Bhargava, R; Ryo, A; Moore, P.S. and Chang, Y. (2016) Survey for human polyomaviruses in cancer. JCI Insight. 1. |  View Abstract

Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 10: 878-889. |  View Abstract

Shuda, M; Feng, H; Kwun, H.J; Rosen, S.T; Gjoerup, O; Moore, P.S. and Chang, Y. (2008) T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci USA. 105: 16272-16277. |  View Abstract

Feng, H; Shuda, M; Chang, Y. and Moore P.S. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 319: 1096-1100. |  View Abstract

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV. Science. 274: 1736-1744. |  View Abstract

Chang, Y; Cesarman, E; Pessin, M. S; Lee, F; Culpepper, J; Knowles, D. M; and Moore, P. S. (1994) Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 266: 1865-1869. |  View Abstract