Jihong Li, PhD

Research Instructor

Dr. Li


Fax: 412-624-1401

447 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219-3143


PhD in Molecular Biology, South China University of Tropical Agriculture, Hainan (P.R. China)

Research Summary

Dr. Li has conducted research on the pathogenesis of C. perfringens diseases originating in the intestines since 2005. During these six years, she completed one four-year USDA grant (Molecular Epidemiology of CPE-Associated Food Poisoning, January 1, 2005 to December 31, 2008) and also worked on two other on-going NIH grants (The Mechanism of Action of Clostridium perfringens enterotoxin and Virulence Plasmids of Clostridium perfringens type B-D). Now she is working on a MARCE grant to study the action of epsilon toxin, a class B select toxin. Her work has produced 19 publications on C. perfringens, of which ten involve first authorship.

Research Lab Affiliation


Li, J; Chen, J; Vidal, J. E; and McClane, B. A. (2011) The Agr-like quorum-sensing system regulates sporulation and production of enterotoxin and beta2 toxin by Clostridium perfringens type A non-food-borne human gastrointestinal disease strain F5603. Infect Immun. 79: 2451-2459. |  View Abstract

Li, J; and McClane, B. A. (2010) Evaluating the involvement of alternative sigma factors SigF and SigG in Clostridium perfringens sporulation and enterotoxin synthesis. Infect Immun. 78: 4286-4293. |  View Abstract

Li, J; Miyamoto, K; Sayeed, S; and McClane, B. A. (2010) Organization of the cpe locus in CPE-positive clostridium perfringens type C and D isolates. PLoS One. 5: e10932. |  View Abstract

Li, J; Paredes-Sabja, D; Sarker, M. R; and McClane, B. A. (2009) Further characterization of Clostridium perfringens small acid soluble protein-4 (Ssp4) properties and expression. PLoS One. 4: e6249. |  View Abstract

Li, J; and McClane, B. A. (2008) A novel small acid soluble protein variant is important for spore resistance of most Clostridium perfringens food poisoning isolates. PLoS Pathog. 4: e1000056. |  View Abstract

Li, J; Miyamoto, K; and McClane, B. A. (2007) Comparison of virulence plasmids among Clostridium perfringens type E isolates. Infect Immun. 75: 1811-1819. |  View Abstract

Li, J; and McClane, B. A. (2006) Comparative effects of osmotic, sodium nitrite-induced, and pH-induced stress on growth and survival of Clostridium perfringens type A isolates carrying chromosomal or plasmid-borne enterotoxin genes. Appl Environ Microbiol. 72: 7620-7625. |  View Abstract