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Research Lab

Apetrei Lab
My laboratory is interested in the study of the HIV/ SIV diversity and pathogenesis. The AIDS pandemic is produced by two different viruses, HIV-1 and HIV-2. These two viruses resulted from cross-species transmissions of SIVs, the viruses that naturally infect nonhuman primate species (NHPs) in Africa. Learn more>
Bomberger Lab
My research program is focused on understanding host-pathogen interactions, and more specifically, how each influences the other during an infection. Emerging evidence reveals that pathogens have the ability to modulate the host response to infection, while at the same time, respond to host defense by altering their virulence and antibiotic resistance. Learn more>
Bernstein Lab
My research into the characterization of lentiviral persistence and pathogenesis is conducted through evolutionary studies of both HIV and EIAV via sequence analysis. Learn more>
Bina Lab
Our research is centered on defining the molecular mechanisms used by bacteria to resist antibiotics and cause disease in humans. Our work currently focuses on two important gram negative human pathogens: Vibrio cholerae and Francisella tularensis. Learn more>
Craigo Lab
Our research started in the characterization of lentiviral persistence and pathogenesis, conducted through evolutionary studies of both HIV and EIAV sequence analysis. Our evolutionary analysis of lentiviral populations via quasispecies sequence analysis included determinations of phenotypic differences of conserved and immunodominant regions of protein variation utilizing multiple computational avenues including: phylogenetics, divergence and selection analyses, and compartmentalization analyses (including Slatkin-Maddison, Mantel and GeneFlow computations). Learn more>
Cooper Lab
The primary goal of our laboratory is to understand how bacterial populations evolve and adapt to colonize hosts and cause disease. We are particularly focused on how bacterial populations form complex communities within biofilms and how cells perceive cues to attach or disperse. We are also developing genome-based diagnostics for bacterial infections. Learn more>
DeLuca Lab
Repression and activation of persisting HSV genomes: Herpes simplex virus can undergo eithera productive infection, where all the viral genes are expressed culminating in the production of progeny virus and cell death, or it can enter a latent state, which is characterized by the relative lack of viral gene expression, genome persistence, and cell survival. Learn more>
Flynn Lab
My primary interest is in the interaction of pathogens with the host, with special emphasis on the immune mechanisms that protect against or exacerbate disease. Our focus is on Mycobacterium tuberculosis, the organism responsible for tuberculosis, which causes 2 million deaths per year worldwide. Learn more>
Glorioso Lab
Dr. Glorioso has established a 35-year history of research related to the basic biology and genetics of herpes simplex virus. His contributions to the field include defining antiviral immune responses to infection, the genetics of viral pathogenesis and latency, and mechanisms of viral infection. Learn more>
Homa Lab
Research in our lab is focused on understanding the mechanism of herpesvirus capsid assembly and DNA packaging. Learn more>
Khan Lab
We are involved in three main areas of research. The first one deals with the role of microRNAs in human papillomavirus-associated cervical and oral cancers as well as role of miRNAs in aging. We are collaborating with several investigators in these studies, including Robert Ferris, Robert Edwards, Laura Niedernhofer and Patricia Opresko. The second area deals with the cellular functions and mechanism of action of the PcrA helicase which is specifically found in Gram-positive bacteria. In these studies, we are collaborating with Drs. Syam Anand and Sanford Leuba. The third area of our interest deals with a molecular analysis of the role of the RepX protein in the replication and segregation of the anthrax toxin-encoding pXO1 plasmid in Bacillus anthracis. Learn more>
Klimstra Lab
The goal of my laboratory has been to define the host and viral factors that determine the success or failure of the innate immune response to infection with arthropod-borne viruses. Learn more>
Lan Lab
To preserve the integrity of the genome, cells have developed various sophisticated mechanisms for repairing damaged DNA. The major DNA repair process that removes helixdistorting lesions from DNA, including UV-induced cyclobutane pyrimidine dimers (CPD) and 6,4 PhotoProducts (6,4-PP) is the nucleotide excision repair (NER) pathway. However, in eukaryotic cells, NER operates on chromatin-embedded DNA substrates and DNA folding with histone proteins into chromatin poses structural constraints likely to challenge detection and repair of DNA lesions. Only recently there has been an emphasis on the relationship of chromatin to NER. Learn more>
Lee Lab
Our lab is studying the RNA-RNA based recruitment mechanism utilized in EBV in greater detail with the goal to extrapolate our findings to the host cell. Learn more>
McClane Lab
Our research is focused on understanding bacterial pathogenesis, which remains a major medical problem in both developing and developed countries. Learn more>
Moore Lab
We study 1) Kaposi’s sarcoma-associated herpesvirus (KSHV), the viral cause of Kaposi’s sarcoma, 2) Merkel cell polyomavirus (MCV), the viral cause of Merkel cell carcinoma and 3) methods to search for undiscovered human tumor viruses. Learn more>
Richardson Lab
The Richardson Lab is primarily focused on the effects of immunometabolism on infectious disease outcomes. Specifically, we study immunometabolism in the context of infections caused by the Gram-positive pathogen Staphylococcus aureus. Learn more>
Sarkar Lab
Innate immunity of an organism is the inborn protection against invading pathogens. Because it is inborn, and entrusted with the protection of host from a vast array of previously unknown invaders, the innate immune system generates a generalized alert response upon pathogen detection. This alert is chemically mediated by a class of molecules called Cytokines. Learn more>
Schmidt Lab
My lab studies the Snf1 kinase of yeast. The mammalian homologue of Snf1 is the AMP-activated protein kinase, an important therapeutic target for type II diabetes. Biochemical and genetic experiments have shown that Snf1 kinase is regulated by phosphorylation of the conserved threonine residue in the kinase activation loop. Learn more>
Smithgall Lab
Research in our laboratory is focused on non-receptor protein-tyrosine kinase structure, function, and inhibitor discovery. Specifically, we are interested in the Src, Abl and Fes kinase families, which were originally discovered in the context of avian transforming retrovirus many years ago. Learn more>
Shair Lab
Epstein-Barr virus (EBV) is an oncogenic γ-herpesvirus that is associated with epithelial and B cell malignancies in humans. The Shair lab studies the molecular mechanisms of cancer induced by this latent virus with the purpose of defining how these mechanisms contribute to the oncogenic and metastatic properties of EBV-associated diseases. Learn more>
Thomas Lab
My research program focuses on signaling pathways that integrate membrane traffic with the regulation of homeostasis and the onset of disease. These studies were grounded by our identification of the proprotein convertase furin, which is the first member of a family of secretory pathway-localized endoproteases that catalyze the activation of bioactive proteins and peptide hormones. Learn more>
Thibodeau Lab
My lab is interested in the fundamental principles of protein structure and dynamics. The acquisition of native protein structure and the dynamics associated with the native state are critical for proper protein biosynthesis and the regulation of protein function. Specifically, we are interested in transmembrane proteins and their roles in human physiology and pathogen virulence. Learn more>
Xiao-Qu Lab
Our primary research interests include the study of signaling transduction pathways in immunity and tumorigenesis, particularly NF-kB, as well as the molecular mechanisms underlying the type-1 human T cell leukemia virus (HTLV-I) mediated T cell transformation for disease prevention and therapeutic purposes. Learn more>
Lakdawala Lab
Our lab studies the molecular properties contributing to the epidemiological success of influenza A viruses to better predict future pandemics. There are two main areas of research in my lab 1) exploring the intracellular dynamics of influenza viral RNA assembly and 2) defining the viral properties necessary for efficient airborne transmission of influenza viruses. Learn more>