Zhaoxia (Julia) Qu, PhD

Research Assistant Professor


Dr. Zhaoxia Qu

Contact

412-623-1749
Fax: 412-623-1415

1.18 Hillman Cancer Center

5117 Center Avenue

Pittsburgh, PA 15232

Education

PhD in Cell Biology and Neuroscience, Rutgers University

Research Summary

Our research interest focuses on the NF-κB signaling pathways.  Given its causative role in the pathogenesis and drug resistance of inflammatory diseases, autoimmune diseases and cancers, NF-κB has been a target of great interest for disease prevention and treatment.  However, it is impractical to block NF-κB activation for disease therapy using ‘classical’ NF-κB inhibitors because of the physiological importance of NF-κB in humans.  Thus, identification of the molecular difference in the pathogenic and physiological activation of NF-κB is necessary for the development of novel approaches to specifically target the pathogenic NF-κB activation for human disease prevention and treatment.  We are addressing this important issue in breast cancer, lung cancer, early T-cell precursor acute lymphoblastic leukemia (ETP-ALL), adult T-cell leukemia (ATL), Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL), for which there is no effective therapy.  We are also actively investigating how NF-κB is deregulated and contributes to the pathogenesis of autoimmune diseases multiple sclerosis (MS) and rheumatoid arthritis (RA), as well as graft-versus-host disease (GVHD).

Research Lab Affiliation

Publications

Qu, Z; Fu, J; Ma, H; Zhou, J; Jin, M; Mapara, M. Y; Grusby, M. J. and Xiao, G. (2012) PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci. 2: 23. |  View Abstract

Huang, B; Qu, Z; Ong, C. W; Tsang, Y. H; Xiao, G; Shapiro, D; Salto-Tellez, M; Ito, K; Ito, Y. and Chen, L. F. (2012) RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor alpha. Oncogene. 31: 527-534. |  View Abstract

Qu, Z; Sun, D; and Young, W. (2011) Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3beta-NF-AT signaling. Cell Biosci. 1: 18. |  View Abstract

Fu, J; Qu, Z; Yan, P; Ishikawa, C; Aqeilan, R. I; Rabson, A. B; and Xiao, G. (2011) The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis. Blood. 117: 1652-1661. |  View Abstract

Qu, Z; Yan, P; Fu, J; Jiang, J; Grusby, M. J; Smithgall, T. E; and Xiao, G. (2010) DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 70: 1766-1772. |  View Abstract

Qu, Z; Fu, J; Yan, P; Hu, J; Cheng, S. Y; and Xiao, G. (2010) Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem. 285: 11786-11792. |  View Abstract

Fu, J; Yan, P; Li, S; Qu, Z; and Xiao, G. (2010) Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis. Onocogene. 29: 6499-6507. |  View Abstract