Sherry Shu, PhD

Research Assistant Professor


Dr. Sherry Shu

Contact

412-648-9240
Fax: 412-624-1401

533 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219

Education

PhD in Veterinary Biosciences, The Ohio State University

MS in Veterinary Biosciences, The Ohio State University

BVM in Veterinary Medicine, National Taiwan University

Research Summary

Investigate the molecular mechanism of action of Nef-directed anti-HIV compounds.

Evaluate the pharmacokinetics, efficacy, and mechanism of action of Nef-directed antiretroviral compounds in a mouse model of AIDS-like disease driven by Nef.

Research Lab Affiliation

Why I Chose Pitt

The mentoring and research environment is excellent. The city of Pittsburgh is fun, family friendly, and affordable. And, of course, the Steelers!

Publications

Emert-Sedlak, L. A; Narute, P; Shu, S. T; Poe, J. A; Shi, H; Yanamala, N; Alvarado, J. J; Lazo, J. S; Yeh, J. I; Johnston, P. A. and Smithgall, T. E. (2013) Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity. Chem Biol. 20: 82-91. |  View Abstract

Pene-Dumitrescu T; Shu S. T; Wales T. E; Alvarado J. J; Shi H; Narute P; Moroco J. A; Yeh J. I; Engen J. R. and Smithgall, T. E. (2012) HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck. BMC Chem Biol. 12: 1. |  View Abstract

Shu, S. T; Dirksen, W. P; Lanigan, L. G; Martin, C. K; Thudi, N. K; Werbeck, J. L; Fernandez, S. A; Hildreth, B. E., 3rd; and Rosol, T. J. (2012) Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1α in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro. Leuk Lymphoma. 53: 688-698. |  View Abstract

Shu, S. T; Sugimoto, Y; Liu, S; Chang, H. L; Ye, W; Wang, L. S; Huang, Y. W; Yan, P; and Lin, Y. C. (2010) Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells. Anticancer Res. 30: 1937-1946. |  View Abstract

Shu, S. T; Martin, C. K; Thudi, N. K; Dirksen, W. P; and Rosol, T. J. (2010) Osteolytic bone resorption in adult T-cell leukemia/lymphoma. Leuk Lymphoma. 51: 702-714. |  View Abstract

Shu, S. T; Nadella, M. V; Dirksen, W. P; Fernandez, S. A; Thudi, N. K; Werbeck, J. L; Lairmore, M. D; and Rosol, T. J. (2007) A novel bioluminescent mouse model and effective therapy for adult T-cell leukemia/lymphoma. Cancer Res. 67: 11859-11866. |  View Abstract