Robert Andrew Baldock, PhD

Postdoctoral Associate


Dr. Robert Baldock

Contact

412-623-3227

2.35 UPCI Research Pavillion

5117 Centre Avenue

Pittsburgh, PA 15232

Education

PhD in Biochemistry, University of Sussex (UK), 2016

BSc with Honors in Molecular Medicine, University of Sussex (UK), 2012

Research Summary

Double-strand breaks (DSBs) are some of the most dangerous and detrimental DNA lesions that can cause genomic instability and potentially lead to the development of cancer. DSBs can be repaired using a number of specialized repair mechanisms such as Homologous Recombination (HR). HR is a high-fidelity DSB repair mechanism that requires a homologous template for repair. During HR, the process of finding and utilizing a homologous repair template in cells is orchestrated by the formation of a RAD51-nucleoprotein filament. RAD51 filament formation is aided by the RAD51 paralogs, proteins that structurally resemble RAD51. My research aims to determine the function(s) of these paralogs in the repair process and to identify factors that regulate their function to maintain genomic stability. 

Research Lab Affiliation

Why I Chose Pitt

University of Pittsburgh Cancer Institute (UPCI) is an environment devoted to understanding cancer with the vision of developing novel therapeutics and identifying genetic risk factors that could be used accurately predict and successfully treat this disease. To aid this process of discovery, the UPCI also has access to the Center for Biologic Imaging, one of the largest microscopy facilities in the country.  I believe continuing my research at the University of Pittsburgh will provide both unique and exciting opportunities to acquire new skills and techniques, as well as allowing me to broaden my professional network. 

Publications

Jongjitwimol J; Baldock R.A; Morley S.J. and Watts F.Z. (2016) Sumoylation of eIF4A2 affects stress granule formation. J Cell Sci. 129: 2407-2415. |  View Abstract

Densham R.M; Garvin A.J; Stone H.R; Strachan J; Baldock R.A; Daza-Martin M; Fletcher A; Blair-Reid S; Beesley J; Johal B; Pearl L.H; Neely R; Keep N.H; Watts F.Z. and Morris J.R. (2016) Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection. Nat Struct Mol Biol. 23: 647-655. |  View Abstract

Baldock R.A; Day M; Wilkinson O.J; Cloney R; Jeggo P.A; Oliver A.W; Watts F.Z. and Pearl L.H. (2015) ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT2 Domain with gammaH2AX. Cell Rep. 13: 2081-2089. |  View Abstract

Watts F.Z; Baldock R; Jongjitwimol J. and Morley S.J. (2014) Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation. Translation (Austin). 2: e959366. |  View Abstract

Jongjitwimol J; Feng M; Zhou L; Wilkinson O; Small L; Baldock R; Taylor D.L; Smith D; Bowler L.D; Morley S.J. and Watts F.Z. (2014) The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2. PLoS One. 9: e94182. |  View Abstract