Julieta Martino, PhD

Postdoctoral Associate


Dr. Julieta Martino

Contact

412-623-3227

2.35 UPCI Research Pavillion

5117 Centre Avenue

Pittsburgh, PA 15232

Education

PhD in Biochemistry and Molecular Biology, University of Maine, 2015

Licentiate in Biology, Universidad Nacional de Cordoba, 2005

Research Summary

My research interests stem from a fascination with cancer biology, particularly the mechanisms that regulate genome stability within a cell. As a toxicologist, I am also interested in how chemicals affect these mechanisms to either induce carcinogenesis or prevent it. My current work at Dr. Bernstein's lab is centered on the regulation of homologous recombination (HR), a highly conserved DNA repair pathway that repairs double-strand breaks (DSBs) with high fidelity. Mutations in proteins involved in HR lead to many hereditary cancers and cancer-prone syndromes such as Fanconi anemia. Specifically, my research focuses on a novel HR protein complex called the Shu complex. The Shu complex is conserved throughout eukaryotes and is likely involved in repairing DSBs formed during DNA replication. Using budding yeast and mammalian cells, I am studying the Shu complex's function during HR.

Research Lab Affiliation

Why I Chose Pitt

As a postdoc, it is very important to be immersed in a productive and positive research environment. Pitt offers outstanding human resources and infrastructure that are key to a successful postdoc experience. Its large medical research community provides the opportunity to be exposed to various disciplines that span from basic science to clinical trials. In addition, we have access to numerous seminars and workshops, state of the art core facilities, and collaboration opportunities. Pitt's postdoc association is also very active, and offers career development support and resources at all stages. Overall, Pitt is a unique, vibrant and friendly academic environment that is highly conducive to a great postdoc experience.

Publications

Martino J. and Bernstein K.A. (2016) The Shu complex is a conserved regulator of homologous recombination. FEMS Yeast Res. [Epub ahead of print] |  View Abstract

Martino J; Holmes A.L; Xie H; Wise S.S. and Wise J.P., Sr. (2015) Chronic Exposure to Particulate Chromate Induces Premature Centrosome Separation and Centriole Disengagement in Human Lung Cells. Toxicol Sci. 147: 490-499. |  View Abstract

Lundquist D; Sironi M; Würsig B; Rowntree V; Martino J. and Lundquist L. (2013) Response of southern right whales to simulated swim-with-whale tourism at Península Valdés, Argentina. Marine Mammal Science. 29: E24–E45. |  View Abstract

Martino J; Wise S.S; Perkins C; Sironi M. and Wise J.P., Sr. (2013) Metal Levels in Southern Right Whale (Eubalaena australis) Skin Biopsies from Península Valdés, Argentina. Journal of Environmental and Analytical Toxicology. 3:190-195. |  View Abstract

Li Chen T; LaCerte C; Wise S.S; Holmes A; Martino J; Wise J.P., Jr; Thompson W.D. and Wise J.P., Sr. (2012) Comparative cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human and sperm whale (Physeter macrocephalus) skin cells. Comp Biochem Physiol C Toxicol Pharmacol. 155: 143-150. |  View Abstract