Heather Rust Dorman, PhD

Postdoctoral Associate


Dr. Heather Rust

Contact

412-648-9240

533 Bridgeside Point II

450 Technology Drive

Pittsburgh, PA 15219

Education

PhD in Chemistry & Biochemistry, University of South Carolina, 2013

BS in Chemistry (Biochemistry), Saint Francis University, 2008

Research Summary

My research focuses on utilizing a fluorescence polarization based high-throughput screening assay to discover small molecule allosteric modulators of the Src family kinases (SFKs), as well as using x-ray crystallography to determine the mechanism of c-Src activation by SH3 domain displacement via a small peptide agonist.

Research Lab Affiliation

Publications

Moroco J.A; Baumgartner M.P; Rust H.L; Choi H.G; Hur W; Gray N.S; Camacho C. and J., Smithgall, T. E. (2014) A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region. Chem Biol Drug Des. [Epub ahead of publishing] |  View Abstract

Rust H.L; Subramanian V; West G.M; Young D.D; Schultz P.G. and Thompson, P. R. (2014) Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. ACS Chem. Biol. 9: 649-655. |  View Abstract

Dillon M.B; Rust H.L; Thompson P.R. and Mowen, K. A. (2013) Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. J Biol Chem. 288: 27872-27880. |  View Abstract

Rust H.L. and Thompson P.R. (2011) Kinase consensus sequences: a breeding ground for crosstalk. ACS Chem Biol. 9: 881-892. |  View Abstract

Rust H.L; Zurita-Lopez C.I; Clarke S. and Thompson P.R. (2011) Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry. 50: 3332-3345. |  View Abstract

Bicker K.L; Obianyo O; Rust H.L. and Thompson P.R. (2011) A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Mol Biosyst. 7: 45-51. |  View Abstract